Can you say “nicotinamide adenine dinucleotide,” 5 times fast? Let me tell you, this anti-aging, cellular restorative therapy is worth the tongue-twisting!
“NAD has emerged as a putative metabolic regulator of transcription, longevity and several age-associated diseases, including diabetes, cancer, and neurodegenerative diseases.”
Su-Ju Lin and Leonard Guarente Current Opinion in Cell Biology 2003, 15:241–246
NAD+ is a B-vitamin derivative and an essential coenzyme (required helper molecule) that is used in every cell in the body to regulate cellular energy metabolism and mitochondrial health. In other words, it’s involved in producing energy, keeping cells alive/healthy and supporting longevity. NAD+ levels decrease during aging and in chronic disease states. Restoring NAD+ levels can aid in recovery from chronic illness and support longevity.
Open any textbook of cellular biochemistry and you will find NAD is a critical biological molecule that participates in many metabolic reactions. If NAD+ is in short supply, NADH (the inactive form) accumulates in the cell and the mitochondria and cell metabolism become dysregulated. Mitochondrial dysfunction is now well recognized as a key feature of many chronic diseases including diabetes, autoimmune disease, addiction, depression and others. Use of supplementary NAD may be an effective strategy for improving cardiovascular and other physiological functions with aging in humans.
Administration of NAD+ intravenously offers improved bioavailability over oral supplementation. It also bypasses the GI tract (gastrointestinal tract), which can be helpful especially for those with chronic GI tract issues, poor absorption, etc.
Dr. Jessica Moore, ND
Dr. Jessica Moore, ND is one of Canada’s only hospital and residency trained naturopathic doctors. She is passionate about disease prevention and supporting patients to feel their best so they can do their best!
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You might also want to read our previous blog, Is It Stress? Food Intolerances? A Gut Bug? Stop Guessing, Get Tested
Su-Ju Lin and Leonard Guarente Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity, and disease Current Opinion in Cell Biology 2003, 15:241–246
Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue. PLoS ONE, 7(7). doi:10.1371/journal.pone.0042357
Martens CR1, Denman BA2, Mazzo MR2, Armstrong ML et al. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Nat Commun. 2018 Mar 29;9(1):1286.